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The
circadian rhythms in complex multicellular organisms are regulated by clock
genes located in the Suprachiasmatic Nucleus (SCN) of hypothalamus, as well as
many other kinds of cells throughout the body. Along with the other two core
clock genes Period (PER) and Cryptochrome (CRY), differentiated embryonic
chondrocyte (DEC)1 and DEC2 participate in the interlocked transcriptional
feedback loop by repressing the CLOCK/ARNTL -induced transactivation of PER1.
Additionally, as the members of basic helix-loop-helix transcription factor
family, DEC1 and DEC2 have been reported to directly or indirectly correlate
with the expression of dozens of genes in different cell types. They also
physically interact with proteins that participate in pathways relevant to carcinogenesis
and/or malignancy progression. DEC1 and DEC2 are widely expressed in both
embryonic and adult tissues. Their expressions are regulated by various
extracellular stimuli, such as grow factors, serum starvation, hypoxia,
hormones, nutrient, cytokines, light, infection. Therefore, they play vital
roles involving development, cell differentiation, cell growth, cell death,
immune systems, homeostasis, metabolic reprogramming, aging and cancer. In
addition, it has been evidenced that mutation at certain position of DEC2 gene
resulted in the short sleep phenotype. Although DEC1 and DEC2 share similarity
at about 40% in their whole protein structure, they functioned differently or
even oppositely when upon the same stimulus. The structural features, functions
and biological roles of DEC1 and DEC2, especially the roles of DEC in various
kinds of malignancy will be discussed.
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